2023年

• Hirano M, Yamada Y.
  Reprogramming of pancreatic islet cells for regeneration and rejuvenation.
  Curr. Opin. Genet. Dev. 2023 Aug 21,82:102099. doi: 10.1016/j.gde.2023.102099.
• Ohta S, Yamada Y.
  Exploring the potential of in vivo reprogramming for studying embryonic development, tissue regeneration, and organismal aging.
  Curr. Opin. Genet. Dev. 2023 Aug 81:102067. doi: 10.1016/j.gde.2023.102067.

2022年

• Ito K, Nagata K, Ohta S, Matsuda Y, Ukai T, Yasuda I, Ota A, Kobayashi R, Kabata M, Sankoda N, Maeda T, Woltjen K, Yang L, Maruyama R, Katayama R, Yamamoto T and Yamada Y
  The oncogene-dependent resinstance to reprogramming unveils cancer therapeutic targets
  Cell Reports 2022 Apr 26 doi:10.1016/j.celrep.2022.110721
• Hirano M, So Y, Tsunekawa S, Kabata M, Ohta S, Sagara H, Sankoda N, Taguchi J, Yamada Y, Ukai T, Kato M, Nakamura J, Ozawa M, Yamamoto T and Yamada Y
  MYCL-mediated reprogramming expands pancreatic insulin-producing cells
  Nature Metabol. 2022 Feb 10 doi:10.1038/s42255-022-00530-y
• Shimada-Takayama Y, Yasuda T, Ukai T, Taguchi J, Ozawa M, Sankoda N, Ohta S and Yamada Y
  Generation of mice for evaluating endogenous p16Ink4a protein expression
  Biochem Biophys Res Commun. 2022 Apr 9 9;599:43-50 doi:10.1016/j.bbrc.2022.02.005
• Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y, Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H and Miura K
  Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats
  Commun Biol. 2022 Mar 30;5(1):287. doi:10.1038/s42003-022-03241-y.

2021年

• Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai M, Yamamoto T and Yamada Y
  DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
  Nature Commun. 2021 Aug 19;12:5041 doi:10.1038/s41467-021-25249-4
• Wakizono T, Nakashima H, Yasui T, Noda T, Aoyagi K, Okada K, Yamada Y, Nakagawa T, Nakashima K.
  Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration.
  JCI Insight. 2021 Nov 22;6(22):e139171 doi: 10.1172/jci.insight.139171.
• Sakai H, Yamada Y, Kubota M, Imai K, Shirakami Y, Tomita H, Hara A, Shimizu M
  The phosphorylated retinoid X receptor-α promotes diethylnitrosamine-induced hepatocarcinogenesis in mice through the activation of β-catenin signaling pathway.
  Carcinogenesis. 2021 Oct 20;bgab099. doi: 10.1093/carcin/bgab099.
• Rovira M, Atla G, Maestro MA, Grau V, Garcia-Hurtado J, Maqueda M, Mosquera JL, Yamada Y, Kerr-Conte J, Pattou F and Ferrer J.
  REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.
  Genes Dev. 2021 Aug 12. doi: 10.1101/gad.348501.121.
• Nakasuka F, Tabata S, Sakamoto T, Hirayama A, Ebi H, Yamada T, Umetsu K, Ohishi M, Ueno A, Goto H, Sugimoto M, Nishioka Y, Yamada Y, Tomita M, Sasaki AT, Yano S, Soga T
  TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers.
  Commun Biol. 2021 Jun 24;4(1):782. doi: 10.1038/s42003-021-02323-7.
• Sankoda N, Tanabe W, Tanaka A, Shibata H, Woltjen K, Chiba T, Haga H, Sakai Y, Mandai M, Yamamoto T, Yamada Y, Uemoto S and Kawaguchi Y
  Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
  Nature Commun. 2021 Jan 25;12(1):560. doi: 10.1038/s41467-021-20906-0.

2020年

• Yagi M, Kabata M, Tanaka A, Ukai T, Ohta S, Nakabayashi K, Shimizu M, Hata K, Meissner A, Yamamoto T, Yamada Y
  Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
  Nature Commun. 2020 Jun 24;doi:10.1038/s41467-020-16989-w
• Omori S, Wang TH, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Seiya I, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A and Nakanishi M
  Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16 high Cells In Vivo
  Cell Metabol. 2020 Nov 3;32(5):814-828.e6. doi: 10.1016/j.cmet.2020.09.006.

2019年

• Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y
  Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor
  Cell Reports 2019 Mar 5;26:2608-2621. doi: 10.1016
• Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y.
  De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency.
  Stem Cell Reports 2019 May 14;12(5):1113-1128. doi: 10.1016
• Komura S, Ito K, Ohta S, Ukai T, Kabata M, Itakura F, Semi K, Matsuda Y, Hashimoto K, Shibata H, Sone M, Jo N, Sekiguchi K, Ohno T, Akiyama H, Shimizu K, Woltjen K, Ozawa M, Toguchida J, Yamamoto Y, Yamada Y.
  Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas
  Nature Commun. 2019 Sep 05;10:3999. doi: 10.1038
• Sakakura M, Ohta S, Yagi M, Tanaka A, Jo N, Woltjen K, Yamamoto T, Yamada Y
  Smarcb1 maintains the cellular identity and the chromatin landscapes of mouse embryonic stem cells.
  Biochem Biophys Res Commun. 2019 Nov 19;519(4):705-713. doi:10.1016

2018年

• Jo N, Sogabe Y, Yamada Y, Ukai T, Kagawa H, Mitsunaga K, Woltjen K, Yamada Y.
  Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling.
  Cancer Sci. 2018 Dec 26. doi: 10.1111/cas.13924.
• Sogabe Y, Seno H, Yamamoto T, Yamada Y.
  Unveiling epigenetic regulation in cancer, aging and rejuvenation with in vivo reprogramming technology
  Cancer Sci. 2018 Sep;109(9):2641-2650. doi: 10.1111/cas.13731.
• Shibata H, Komura S, Yamada Y, Sankoda N, Tanaka A, Ukai T, Kabata M, Sakurai S, Kuze B, Woltjen K, Haga H, Ito Y, Kawaguchi Y, Yamamoto T, Yamada Y.
  In vivo reprogramming drives Kras-induced cancer development.
  Nature Commun. 2018 May 25;9(1):2081. doi: 10.1038/
• Yamada Y, Yamada Y.
  The causal relationship between epigenetic abnormality and cancer development:in vivo reprogramming and its future application
  Proc Jpn Acad Ser B Phys Biol Sci. 2018;94(6):235-247. doi:10.2183
• Ikeda T, Hikichi T, Miura H, Shibata H, Mitsunaga K, Yamada Y, Woltjen K, Miyamoto K, Watanabe A, Hiratani I, Yamada Y, Yamamoto T, Hotta A, Okita K, Masui S.
  Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs.
  Nature Commun. 2018 Apr 11;9(1):1387. doi: 10.1038/
• Hino K, Zhao C, Horigome K, Nishio M, Okanishi Y, Nagata S, Komura S, Yamada Y, Toguchida J, Ohta A, Ikeya M.
  An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva.
  Stem Cell Reports. 2018 Nov 13;11(5):1106-1119. doi: 10.1016/j.stemcr.2018.10.007.
• Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Matsue H, Nakahata T, Saito MK.
  Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.
  J. Allergy Clin. Immunol. 2018 Jan;141(1):339-349.e11. doi: 10.1016/j.jaci.2017.04.013.

2017年

• Taguchi J, Yamada Y.
  In vivo reprogramming for tissue regeneration and organismal rejuvenation.
  Curr Opin Genet Dev. 2017 Oct;46:132-140. doi: 10.1016/j.gde.2017.07.008. Epub 2017 Aug 2.
• Yagi M, Yamanaka S, Yamada Y.
  Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency.
  Lab Invest. 2017 Oct;97(10):1133-1141. doi: 10.1038/labinvest.2017.87. Epub 2017 Sep 4.
• Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y.
  Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation.
  Nature 2017 Aug 10;548(7666):224-227. doi: 10.1038/nature23286. Epub 2017 Jul 26
• Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, *Yamamoto T.
  Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
  Cell Metab. 2017 May 2;25(5):1103-1117.
• Ito K, Yamada Y.
  Cellular reprogramming technology for dissecting cancer epigenome in vivo.
  Epigenomics. 2017 Jul;9(7):997-1011. doi: 10.2217/epi-2017-0018. Epub 2017 Jun 27.
• Taguchi J, Yamada Y.
  Unveiling the role of senescence-induced cellular plasticity.
  Cell Stem Cell(Preview) 2017 20(3):293-294. (Preview)
• Hashimoto K, Yamada Y, Semi K, Yagi M, Tanaka A, Itakura F, Aoki H, Kunisada T, Woltjen K, Haga H, Sakai Y, Yamamoto T, Yamada Y.
  Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.
  Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):758-763.
• Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J, Ikeya M.
  Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.
  J. Clin. Invest. 2017 Sep 1;127(9):3339-3352. doi: 10.1172/JCI93521.
• Arioka Y, Ito H, Hirata A, Semi K, Yamada Y, Seishima M.
  Behavior of leucine-rich repeat-containing G-protein coupled receptor 5-expressing cells in the reprogramming process.
  Stem Cell Res. 2017 Apr;20:1-9. doi: 10.1016/j.scr.2017.01.012. Epub 2017 Feb 4.
• Kawamata M, Katsuda T, Yamada Y, Ochiya T
  In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules.
  Biochem. Biophys. Res. Commun. 2017 Jan 22;482(4):750-757.

2016年

• Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y.
  EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development.
  Stem Cell Reports. 2016 6(4):592-606.
• Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F, Toyoda T, Matsui S, Araoka T, Yasuno T, Mae S, Kobayashi H, Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N, Inoue S, Yamamoto T, Takahashi K, Asaka I, Yamada Y, Ubara Y, Muso E, Fukatsu A, Watanabe A, Sato Y, Nakahata T, Mori Y, Koizumi A, Nakao K, Yamanaka S, Osafune K.
  Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models.
  Sci. Rep. 2016 Jul 15;6:30013.

2015年

• Semi K, Yamada Y.
  Induced pluripotent stem cell technology for dissecting the cancer epigenome.
  Cancer Sci. 2015 Oct;106(10):1251-6. doi: 10.1111/cas.12758.
• Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.
  Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation.
  Carcinogenesis. 2015 Jul;36(7):719-29. doi: 10.1093/carcin/bgv060.
• Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.
  Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation.
  Carcinogenesis. 2015 Jul;36(7):719-29. doi: 10.1093/carcin/bgv060.
• Kim SI, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, Yamamoto T, Yamanaka S, Woltjen K.
  KLF4 N-terminal variance modulates induced reprogramming to pluripotency.
  Stem Cell Reports 2015 Apr 14;4(4):727-43.

2014年

• Matsuda Y, Semi K, Yamada Y.
  Application of iPS cell technology to cancer epigenome study: Uncovering the mechanism of cell status conversion for drug resistance in tumor.
  Pathol Int. 2014 Jul;64(7):299-308. doi: 10.1111/pin.12180.
• Ohnishi K, Semi K, Yamada Y.
  Epigenetic regulation leading to induced pluripotency drives cancer development in vivo.
  Biochem Biophys Res Commun. 2014 Jul 11
• Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y.
  Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation.
  Cell. 2014 156 (4): 663-677

2013年

• Yamada K, Ohno T, Aoki H, Semi K, Watanabe A, Moritake H, Shiozawa S, Kunisada T, Kobayashi Y, Toguchida J, Shimizu K, Hara A, Yamada Y.
  EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.
  Journal Of Clinical Investigation. 2013 123 (2): 600-610
• Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y.
  Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.
  Development 2013 140 (1):66-75
• Semi K, Matsuda Y, Ohnishi K, Yamada Y.
  Cellular reprogramming and cancer development.
  International Journal Of Cancer. 2013 132 (6): 1240-1248
• Yamaji M, Ueda J, Hayashi K, Ohta H, Yabuta Y, Kurimoto K, Nakato R, Yamada Y, Shirahige K, Saitou M.
  PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.
  Cell Stem Cell 12(3):368-82, 2013.
• Koyanagi-Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, *Yamanaka S.
  Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.
  Proc. Natl. Acad. Sci. U. S. A. 110(51):20569-74, 2013.

〜2012年

• Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H.
  Drug screening for ALS using patient-specific induced pluripotent stem cells.
  Science Transl. Med. Aug 1;4(145):145ra104, 2012.
• Aoki H, Hara A, Era T, Kunisada T and *Yamada Y.
  Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis.
  Development 139(4):667-77, 2012.
• Yamada Y, Watanabe A.
  Epigenetic codes in stem cells and cancer stem cells.
  Adv Genet. 2010;70:177-99.
• Yasuhiro Yamada, Hitomi Aoki, Takahiro Kunisada and Akira Hara.
  Rest promotes the early differentiation of mouse ESCs but is not required for their maintenance.
  Cell Stem Cell. 6(1) pp.10-15 2010-01-08
• Baba S, Yamada Y, Hatano Y, Miyazaki Y, Mori H, Shibata T, Hara A.
  Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus.
  Cancer Sci. 2009, Epub ahead of print
• Oyama T, Yamada Y, Hata K, Tomita H, Hirata A, Sheng HQ, Hara A, Aoki H, Kunisada T, Yamashita S, Mori H.
  Further upregulation of ß-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of Apc Min/+ mice.
  Carcinogenesis. 29:666-672, 2008
• Hara A, Aoki H, Taguchi A, Niwa M, Yamada Y, Kunisada T, Mori H.
  Neuron-like Differentiation and Selective Ablation of Undifferentiated Embryonic Stem Cells Containing Suicide Gene with Oct-4 Promoter.
  Stem Cells Dev. 17(4):619-27, 2008.
• Tomita H, Kuno T, Yamada Y, Oyama T, Asano N, Miyazaki Y, Baba S, Taguchi A, Hara A, Iwasaki T, Kobayashi H, Mori H.
  Preventive effect of fermented brown rice and rice bran on N-methyl-N’-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.
  Oncol Rep. 19:11-15, 2008
• Miyazaki Y, Hara A, Kato K, Oyama T, Yamada Y, Mori H, Shibata T.
  The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma.
  Int J Oncol. 32:145-151, 2008
• Linhart HG, Lin H, Yamada Y, Moran E, Steine EJ, Gokhale S, Lo G, Cantu E, Ehrich M, He T, Meissner A, Jaenisch R.
  Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.
  Genes Dev. 21:3110-3122, 2007
• Tomita H, Yamada Y, Oyama T, Hata K, Hirose Y, Hara A, Kunisada T, Sugiyama Y, Adachi Y, Linhart H, Mori H.
  Development of gastric tumors in Apc Min/+ mice by the activation of the ß-catenin/Tcf signaling pathway.
  Cancer Res. 67:4079-87, 2007
• Yamada Y, Mori H.
  Multistep carcinogenesis in the colon of Apc Min/+ mouse
  Cancer Sci. 98:6-10, 2007.
• Asano N, Kuno T, Hirose Y, Yamada Y, Yoshida K, Tomita H, Nakamura Y, Mori H.
  Preventive Effects of a Flavonoid Myricitrin on the Formation of Azoxymethane-induced Premalignant Lesions in Colons of Rats.
  Asian Pac J Cancer Prev. 8:73-76, 2007
• Hara A, Taguchi A, Niwa H, Aoki H, Yamada Y, Ito H, Nagata K, Kunisada T, Mori H.
  Localization of septin 8 in murine retina, and spatiotemporal expression of septin 8 in a murine model of photoreceptor cell degeneration.
  Neurosci Lett. 423: 205-210, 2007
• Sheng H, Hirose Y, Hata K, Zheng Q, Kuno T, Asano N, Yamada Y, Hara A, Osawa T, Mori H.
  Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon.
  Cancer Lett. 246:63-68, 2007
• Zhi H, Yamada Y, Hirose Y, Kato K, Sheng H, Zheng Q, Oyama T, Asano N, Kuno T, Hara A, Mori H.
  Effect of 2-(carboxyphenyl) retinamide and genistein on the formation of early lesions in 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
  Asian Pac J Cancer Prev. 8:33-38, 2007
• Lin H*, Yamada Y*, Nguyen S, Linhart H, Jackson-Grusby L, Meissner A, Meletis K, Lo G, Jaenisch R.
  Suppression of Intestinal Neoplasia by Deletion of Dnmt3b.
  Mol Cell Biol, 26:2976-2983, 2006 *These authors are equally contributed to this work.
• Hata K, Tanaka T, Kohno H, Suzuki R, Qiang SH, Yamada Y, Oyama T, Kuno T, Hirose Y, Hara A, Mori H.
  beta-Catenin-accumulated crypts in the colonic mucosa of juvenile Apc(Min/+) mice.
  Cancer Lett. 239:123-128, 2006
• Kuno T, Hirose Y, Yamada Y, Hata K, Qiang SH, Asano N, Oyama T, Zhi H, Iwasaki T, Kobayashi H, Mori H.
  Chemoprevention of mouse urinary bladder carcinogenesis by the fermented brown rice and rice bran.
  Oncol Rep. 15:533-538, 2006
• Hochedlinger K*, Yamada Y*, Beard C, Jaenisch R. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.
  Cell. 2005 May 6;121(3):465-77. *These authors are equally contributed to this work.
• Yamada Y, Jackson-Grusby L, Linhart H, Meissner A, Eden A, Lin H, Jaenisch R.
  Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.
  Proc Natl Acad Sci U S A. 2005 102(38):13580-5.
• Holm T, Jackson-Grusby L, Brambrink T, Yamada Y, Rideout III W, Jaenisch R.
  Global loss of imprinting leads to widespread tumorigenesis in adult mice.
  Cancer Cell. 2005 Vol 8, 275-285.
• Hara A, Sakata K, Yamada Y, Kuno T, Kitaori N, Oyama T, Hirose Y, Murakami A, Tanaka T, Mori H.
  Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats.
  Oncol Rep. 2005 Aug;14(2):345-51.
• Mori H, Hata K, Yamada Y, Kuno T, Hara A.
  Significance and role of early-lesions in experimental colorectal carcinogenesis.
  Chem Biol Interact. 2005 Jun 30;155(1-2):1-9. Review.
• Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R.
  Reprogramming of a melanoma genome by nuclear transplantation.
  Genes Dev. 2004 Aug 1;18(15):1875-85.
• Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R.
  Nuclear cloning of embryonal carcinoma cells.
  Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):13985-90.
• Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K.
  Nuclear cloning, epigenetic reprogramming, and cellular differentiation.
  Cold Spring Harb Symp Quant Biol. 2004;69:19-27.
• Yoshimi N, Morioka T, Kinjo T, Inamine M, Kaneshiro T, Shimizu T, Suzui M, Yamada Y, Mori H.
  Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride.
  Cancer Sci. 2004 Oct;95(10):792-7.
• Sakata K, Hara A, Hirose Y, Yamada Y, Kuno T, Katayama M, Yoshida K, Zheng Q, Murakami A, Ohigashi H, Ikemoto K, Koshimizu K, Tanaka T, Mori H.
  Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis.
  Oncology. 2004;66(3):244-52.
• Mori H, Yamada Y, Kuno T, Hirose Y.
  Aberrant crypt foci and beta-catenin accumulated crypts; significance and roles for colorectal carcinogenesis.
  Mutat Res. 2004 May;566(3):191-208. Review.
• Hata K, Yamada Y, Kuno T, Hirose Y, Hara A, Qiang SH, Mori H.
  Tumor formation is correlated with expression of beta-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice.
  Cancer Sci. 2004 Apr;95(4):316-20.
• Hirose Y, Hata K, Kuno T, Yoshida K, Sakata K, Yamada Y, Tanaka T, Reddy BS, Mori H.
  Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice.
  Carcinogenesis. 2004 May;25(5):821-5.
• Kato H, Kanematsu M, Kondo H, Osada S, Goshima S, Yamada T, Yamada Y, Yokoyama R, Hoshi H, Moriyama N.
  Inflammatory pseudotumor of the liver: ferumoxide-enhanced MR imaging as a tiebreaker.
  J Magn Reson Imaging. 2004 Sep;20(3):501-5.
• Yoshida K, Hirose Y, Tanaka T, Yamada Y, Kuno T, Kohno H, Katayama M, Qiao Z, Sakata K, Sugie S, Shibata T, Mori H.
  Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide.
  Cancer Sci. 2003 Apr;94(4):365-71.
• Yamada Y, Mori H.
  Pre-cancerous lesions for colorectal cancers in rodents: a new concept.
  Carcinogenesis. 2003 Jun;24(6):1015-9. Review.
• Kanematsu M, Matsuo M, Yamada Y, Semelka RC, Kondo H, Goshima S, Hoshi H, Moriyama N.
  Perilesional hyperintense rim of malignant hepatic tumors on ferumoxide-enhanced T1-weighted gradient-echo MR images: correlation between MR imaging and histopathologic findings.
  J Magn Reson Imaging. 2003 Jul;18(1):40-8.
• Mori H, Yamada Y, Hirose Y, Kuno T, Katayama M, Sakata K, Yoshida K, Sugie S, Hara A, Yoshimi N.
  Chemoprevention of large bowel carcinogenesis; the role of control of cell proliferation and significance of beta-catenin-accumulated crypts as a new biomarker.
  Eur J Cancer Prev. 2002 Aug;11 Suppl 2:S71-5. Review.
• Hirose Y, Kuno T, Yamada Y, Sakata K, Katayama M, Yoshida K, Qiao Z, Hata K, Yoshimi N, Mori H.
  Azoxymethane-induced beta-catenin-accumulated crypts in colonic mucosa of rodents as an intermediate biomarker for colon carcinogenesis.
  Carcinogenesis. 2003 Jan;24(1):107-11.
• Yamada Y, Oyama T, Hirose Y, Hara A, Sugie S, Yoshida K, Yoshimi N, Mori H.
  beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.
  Carcinogenesis. 2003 Jan;24(1):91-7.
• Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H.
  A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate.
  Cancer Sci. 2003 Nov;94(11):965-73.
• Katayama M, Sugie S, Yoshimi N, Yamada Y, Sakata K, Qiao Z, Iwasaki T, Kobayashi H, Mori H.
  Preventive effect of fermented brown rice and rice bran on diethylnitrosoamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
  Oncol Rep. 2003 Jul-Aug;10(4):875-80.
• Kuno T, Hirose Y, Yamada Y, Yoshida K, Qiao Z, Katayama M, Sakata K, Hara A, Sugie S, Mori H.
  Promoting effects of high-fat corn oil and high-fat mixed lipid diets on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in F344 rats.
  Oncol Rep. 2003 May-Jun;10(3):699-703.
• Katayama M, Hara A, Hirose Y, Yamada Y, Kuno T, Sakata K, Morioka T, Inamine M, Shibuya C, Mori H, Yoshimi N.
  Carcinoid tumor in the female urethral orifice: rare case report and a review of the literature.
  Pathol Int. 2003 Feb;53(2):102-5.
• Yamada Y, Hata K, Hirose Y, Hara A, Sugie S, Kuno T, Yoshimi N, Tanaka T, Mori H.
  Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.
  Cancer Res. 2002 Nov 15;62(22):6367-70.
• Kuno T, Yamada Y, Hirose Y, Katayama M, Sakata K, Hara A, Saji S, Mori H.
  Induction of apoptosis by sulindac in azoxymethane-induced possible colonic premalignant lesions in rats.
  Jpn J Cancer Res. 2002 Mar;93(3):242-6.
• Tanaka T, Kohno H, Sakata K, Yamada Y, Hirose Y, Sugie S, Mori H.
  Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
  Carcinogenesis. 2002 Aug;23(8):1361-7.
• Vinh PQ, Sugie S, Tanaka T, Hara A, Yamada Y, Katayama M, Deguchi T, Mori H.
  Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice.
  Jpn J Cancer Res. 2002 Jan;93(1):42-9.
• Matsunaga K, Katayama M, Sakata K, Kuno T, Yoshida K, Yamada Y, Hirose Y, Yoshimi N, Mori H.
  Inhibitory Effects of Chlorogenic Acid on Azoxymethane-induced Colon Carcinogenesis in Male F344 Rats.
  Asian Pac J Cancer Prev. 2002;3(2):163-166.
• Katayama M, Yoshimi N, Yamada Y, Sakata K, Kuno T, Yoshida K, Qiao Z, Vihn PQ, Iwasaki T, Kobayashi H, Mori H.
  Preventive effect of fermented brown rice and rice bran against colon carcinogenesis in male F344 rats.
  Oncol Rep. 2002 Jul-Aug;9(4):817-22.
• Yanaida Y, Kohno H, Yoshida K, Hirose Y, Yamada Y, Mori H, Tanaka T.
  Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
  Carcinogenesis. 2002 May;23(5):787-94.
• Mori H, Niwa K, Zheng Q, Yamada Y, Sakata K, Yoshimi N.
  Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells.
  Mutat Res. 2001 Sep 1;480-481:201-7.
• Yamada Y, Yoshimi N, Hirose Y, Hara A, Shimizu M, Kuno T, Katayama M, Qiao Z, Mori H.
  Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib.
  Jpn J Cancer Res. 2001 Jun;92(6):617-23.
• Yamada Y, Yoshimi N, Hirose Y, Matsunaga K, Katayama M, Sakata K, Shimizu M, Kuno T, Mori H.
  Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis.
  Cancer Res. 2001 Mar 1;61(5):1874-8.
• Shimizu M, Hara A, Okuno M, Matsuno H, Okada K, Ueshima S, Matsuo O, Niwa M, Akita K, Yamada Y, Yoshimi N, Uematsu T, Kojima S, Friedman SL, Moriwaki H, Mori H.
  Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis.
  Hepatology. 2001 Mar;33(3):569-76.
• oshimi N, Matsunaga K, Katayama M, Yamada Y, Kuno T, Qiao Z, Hara A, Yamahara J, Mori H.
  The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats.
  Cancer Lett. 2001 Feb 26;163(2):163-70.
• Yamada Y, Yoshimi N, Hirose Y, Kawabata K, Matsunaga K, Shimizu M, Hara A, Mori H.
  Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis.
  Cancer Res. 2000 Jul 1;60(13):3323-7.
• Kawabata K, Yamamoto T, Hara A, Shimizu M, Yamada Y, Matsunaga K, Tanaka T, Mori H.
  Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats.
  Cancer Lett. 2000 Aug 31;157(1):15-21.
• Hara A, Yoshimi N, Yamada Y, Matsunaga K, Kawabata K, Sugie S, Mori H.
  Effects of Fas-mediated liver cell apoptosis on diethylnitrosamine-induced hepatocarcinogenesis in mice.
  Br J Cancer. 2000 Jan;82(2):467-71.
• Matsunaga K, Yoshimi N, Shimoi K, Yamada Y, Katayama M, Sakata K, Kumo T, Yoshida K, Qiao Z, Kinae N, Mori H.
  Inhibitory Effects of Dietary Monoglucosyl-rutin on Azoxymethane-induced Colon Carcinogenesis in Rats.
  Asian Pac J Cancer Prev. 2000;1(3):211-216.
• Kawabata K, Tanaka T, Murakami T, Okada T, Murai H, Yamamoto T, Hara A, Shimizu M, Yamada Y, Matsunaga K, Kuno T, Yoshimi N, Sugie S, Mori H.
  Dietary prevention of azoxymethane-induced colon carcinogenesis with rice-germ in F344 rats.
  Carcinogenesis. 1999 Nov;20(11):2109-15.
• Yamada Y, Yoshimi N, Sugie S, Suzui M, Matsunaga K, Kawabata K, Hara A, Mori H.
  Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.
  Jpn J Cancer Res. 1999 Aug;90(8):824-8.
• Yoshimi N, Shimizu M, Matsunaga K, Yamada Y, Fujii K, Hara A, Mori H.
  Chemopreventive effect of N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide (NS-398), a selective cyclooxygenase-2 inhibitor, in rat colon carcinogenesis induced by azoxymethane.
  Jpn J Cancer Res. 1999 Apr;90(4):406-12.
• Shimizu M, Yoshimi N, Yamada Y, Matsunaga K, Kawabata K, Hara A, Moriwaki H, Mori H.
  Suppressive effects of chlorogenic acid on N-methyl-N-nitrosourea-induced glandular stomach carcinogenesis in male F344 rats.
  J Toxicol Sci. 1999 Dec;24(5):433-9.
• Mori H, Matsunaga K, Tanakamaru Y, Kawabata K, Yamada Y, Sugie S, Nishikawa A.
  S-methylmethanethiosulfonate or 5-hydroxy-4-(2-phenyl-(E)ethenyl)-2(5H)-furanone(KYN-54) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in mice.
  Cancer Lett. 1999 Jan 29;135(2):123-7.
• Matsunaga K, Yoshimi N, Yamada Y, Shimizu M, Kawabata K, Ozawa Y, Hara A, Mori H.
  Inhibitory effects of nabumetone, a cyclooxygenase-2 inhibitor, and esculetin, a lipoxygenase inhibitor, on N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats.
  Jpn J Cancer Res. 1998 May;89(5):496-501.
• Yoshimi N, Kawabata K, Hara A, Matsunaga K, Yamada Y, Mori H.
  Inhibitory effect of NS-398, a selective cyclooxygenase-2 inhibitor, on azoxymethane-induced aberrant crypt foci in colon carcinogenesis of F344 rats.
  Jpn J Cancer Res. 1997 Nov;88(11):1044-51.

 

ページトップ