Epigenetic regulation plays a critical role in cell fate specification during normal development and stable maintenance of somatic cell fate. Impairment in epigenetic regulation is often involved in various diseases such as cancer. Recent studies also imply that altered epigenetic regulation is associated with aging phenotypes. Together, the maintenance of proper epigenetic regulation is crucial for the healthy life of multicellular organisms.

The development of reprogramming technologies, as represented by iPS cell technology, has enabled to control somatic cell fate. The reprogramming process involves dynamic reorganization of epigenetic modifications. Taking advantage of reprogramming technologies, we have devised reprogrammable mouse models in which epigenetic regulation, and eventually cell fate, can be altered in vivo. By inducing perturbation of epigenetic regulation and a cellular identity at the organismal level, we aim to elucidate the impact of epigenomic regulation in pathogenesis and the aging process.

Finally, we aim to develop a means for disease treatment, tissue regeneration, and rejuvenation through epigenetic regulation with reprogramming technologies.

Our effort should promote interdisciplinary research that connects a wide range of research fields, including stem cell biology, immunology, and cancer biology, which eventually contributes to the development of novel strategies to control the detrimental effects of diseases and aging in humans.

 

 

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